Treating muscle weakness in knee osteoarthritis and surgical patients

“I have been using the CyMedica System for patients undergoing partial and total knee replacement. There is good evidence that pre-operative physical therapy can enhance post-operative recovery after knee replacement…”

David Mayman, MD
Hospital for Special Surgery, New York, NY

“With regular use, QB1 technology accelerates patients’ rehab and gets patients back to their active lifestyles.”

Struan Coleman, MD
Hospital for Special Surgery, New York, NY

“Quadriceps atrophy is a huge problem for our patients following knee surgery and the CyMedica QB1 provides a new opportunity to promote early recovery with a device that my patients look forward to using.”

Brian J. Cole, MD, MBA,
Rush University Medical Center, Chicago, IL

“With quadriceps there is a local and central inhibition mechanism and I think the CyMedica system with daily use is undoing the inhibition locally and possibly even centrally. Last patient I saw yesterday came in from palm beach- had total knee done few months back with horrible extension lag- for eight weeks he has been doing CyMedica NMES therapy 20 mins twice daily and the lag is almost gone.”

Vijay Vad, MD
Hospital for Special Surgery, New York, NY

The Challenges of Muscle Weakness

Muscle weakness is considered one of the most prevalent clinical conditions associated with knee osteoarthritis and the rehabilitation challenges facing patients recovering from knee procedures.

  • Patients can lose over 60% of their quadriceps strength after knee surgery, and clinic physical therapy programs alone may not always be successful in restoring critical muscle activation strength1.
  • In patients with pre-operative knee osteoarthritis, upper leg muscle strength is reported to be approximately 20–40% lower compared with healthy age-matched controls2. Muscle weakness in knee OA is strongly related to the patient-reported outcomes pain, activity limitations and falls, and has been linked to symptomatic progression of the disease.

CyMedica NMES is Clinically Proven

NMES therapy has been demonstrated to be clinically effective by increasing muscle strength post-surgery, during pre-hab and rehab. Designed to overcome the comfort and convenience barrier of traditional NMES, our advanced NMES solutions empower patients to be engaged in therapy at home and keep track of their progress.

A recent study from Cleveland Clinic shows the use of CyMedica e-vive NMES System following total knee replacement surgery for quadriceps strengthening allowed an earlier return to function in patients3:

We invest heavily in research to show the positive impact of muscle strengthening.

Recruiting Clinical Trials

Neuromuscular Electrical Stimulation Use after Total Knee Arthroplasty Improves Early Return to Function: A Randomized Trial

Statistically significant +12.9 increase in quadriceps strength at 3 week postoperative point:


Statistically significant improvement in TUG Test Time at 6 and 12 week postoperative points:


Economically Validated

Patients with significant muscle atrophy can cost up to $4,200 more for post-surgery rehabilitation than those who do not suffer with significant muscle loss4. This reinforces the need for solutions that engage patients in their rehabilitation in order to minimize complications that could lead to readmission.



Patient Engagement from Home

We partner with healthcare providers to engage patients in strengthening their muscles from home to minimize pre- and postsurgical atrophy.

Supporting research has shown that consistent NMES therapy and patient engagement post- knee surgery may help patients attain and exceed their preoperative activity levels. The use of NMES in addition to progressive strengthening exercises has shown promising results and should be provided to attenuate the early loss of quadriceps strength after TKA5.



Clinical Research

See how muscle strengthening can positively impact patient progress and return to activity.

Latest Studies

Reimbursement & Coding Information

Reimbursement Code + Description
Adjustable knee joint (hinge)
Form fitting conductive garment
Neuromuscular electrical stimulation (NMES)
Remote monitoring of physiologic parameter(s) (eg, weight, blood pressure, pulse oximetry, respiratory flow rate), initial; set-up and patient education on use of equipment.
Remote patient monitoring treatment management services, 20 minutes or more of clinical staff/physician/other qualified healthcare professional time in a calendar month requiring interactive communication with the patient/caregiver during the month.

For more information on reimbursement of the CyMedica NMES solutions, please visit:

Reimbursement Resource Guide

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